Steven Parrish, a senior vice president of Philip Morris, said yesterday that [Victor DeNoble] had changed his opinions over time, making his findings more dramatic than they were. "That Dr. DeNoble has now conveniently changed his opinions does not change the facts of what his Philip Morris research showed," Parrish said.
Working with fellow scientist Paul Mele, DeNoble conducted studies on rats to see whether they would self-administer nicotine intravenously by pressing levers in their cages. They found that the rats frequently did so, much more often then when a saline solution was made available in the same manner, and that nicotine had a positive reinforcing effect, DeNoble testified.
DeNoble and Mele said they had been led to believe they could publish work in journals while working for Philip Morris. But in 1983, when they sought to publish a paper in Psychopharmacology, they said they were told by Philip Morris they could not do so.
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