As part of a so-called surge in personnel, the CIA deployed as many as 50 clandestine operatives to Pakistan and Afghanistan -- a dramatic increase over the number of CIA case officers permanently stationed in those countries. All of the new arrivals were given the primary objective of finding what counter-terrorism officials call "HVT1" and "HVT2." Those "high value target" designations refer to Bin Laden and Zawahiri.

"We've had no significant report of him being anywhere," said a former senior CIA official who, like others interviewed for this article, spoke on condition of anonymity when discussing U.S. intelligence operations. U.S. spy agencies have not even had information that "you could validate historically," the official said, meaning a tip on a previous Bin Laden location that could subsequently be verified.

"Everything was undermined by the so-called peace agreement in north Waziristan," said a senior U.S. intelligence official responsible for overseeing counter-terrorism operations. "Of all the things that work against us in the global war on terror, that's the most damaging development. The one thing Al Qaeda needs to plan an attack is a relatively safe place to operate."