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Chronic fatigue syndrome: a little-understood disease
[FINAL Edition]
The Sun - Baltimore, Md.
Author: Foreman, Judy
Date: Sep 9, 2005
Start Page: 2.D
Section: HEALTH & SCIENCE
Abstract (Document Summary)

Like [Jean Harrison], many people with chronic fatigue are first told they have depression. But the afflictions are quite different - for example, depression triggers an increase in the stress hormone cortisol, while chronic fatigue produces a decline, said Harvard's [Anthony Komaroff]. While depression gets better with drugs such as Prozac, the fatigue of CFS does not.

Harrison's perplexing response to exercise is also typical of many chronic fatigue patients - exercise triggers the release of fatigue-inducing immune chemicals called cytokines. People with the disease sometimes can exercise as hard as healthy people, but they feel awful for a day or two afterward, [William Reeves] said.

In research published last spring, Christopher Snell at the University of the Pacific in Stockton, Calif., showed that some people with chronic fatigue syndrome experience a flare-up of symptoms after exercise. Paradoxically, though, a 2004 analysis of data pooled from five separate studies showed that very gradual increases in aerobic exercise can reduce fatigue in some patients.

 Buy Complete Document:   AbstractAbstract Full Text Full Text

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