WASHINGTON -- Negotiators working over the weekend agreed Sunday on major provisions of a bill to create the nation's first comprehensive tobacco control policy.

The bill aims to reduce underage smoking, regulate nicotine as a drug, drastically alter the tone and reach of cigarette advertising and pay tobacco farmers for the loss of income due to the strict controls.

If the measure, sponsored by Sen. John McCain, R-Ariz., becomes law, it will cost cigarette manufacturers $506 billion over 25 years to settle health claims. That's almost $140 billion more than the tobacco industry pledged in a deal arranged last June with 40 state attorneys general.